Laohapand T, Osman E M, Morley A R, Ward M K, Kerr D N
Proc Eur Dial Transplant Assoc. 1983;19:143-52.
A retrospective autopsy study of 78 patients treated by some form of dialysis for chronic renal failure in Newcastle 1964-1981 showed that: 1) Particles resembling silicone elastomer were present in 48 per cent of 61 patients haemodialysed with the use of silicone rubber pump inserts but in none of the 11 treated by haemodialysis with other pump inserts or of the six treated by peritoneal dialysis alone; 2) The prevalence of these particles and their density increased with time on haemodialysis; 3) There was little evidence of a tissue reaction to the particles and no association between their presence and histological evidence of liver disease; 4) There was a higher incidence of clinical and biochemical evidence of liver disease in patients with silicone deposits than in those without. Although there are other possible explanations for this higher incidence of hepatic dysfunction it would be safer to assume that silicone particle spallation is not innocuous.
一项对1964年至1981年在纽卡斯尔接受某种形式透析治疗慢性肾衰竭的78例患者进行的回顾性尸检研究表明：1）在使用硅橡胶泵插入物进行血液透析的61例患者中，48%的患者体内存在类似硅酮弹性体的颗粒，而在使用其他泵插入物进行血液透析的11例患者或仅接受腹膜透析的6例患者中均未发现；2）这些颗粒的患病率及其密度随着血液透析时间的延长而增加；3）几乎没有证据表明组织对这些颗粒有反应，且它们的存在与肝病的组织学证据之间没有关联；4）有硅酮沉积物的患者出现肝病临床和生化证据的发生率高于没有硅酮沉积物的患者。尽管对于这种肝功能障碍较高的发生率可能有其他解释，但假设硅酮颗粒剥落并非无害会更安全。
