[慢性血液透析患者脾脏中的硅质包涵体]

[Silicone inclusions in the spleen in a patient under chronic hemodialysis].

作者信息

Gosselin B, Tacquet A, Servais B, Vilain M O, Le Maguer D, Dequiedt P, Delerive C, Benoit O

出版信息

Ann Pathol. 1985;5(4-5):299-304.

Abstract

A 67-year-old woman with chronic renal failure, in periodic hemodialysis, presented an hemolytic anemia in relation to splenic sequestration. Light Microscopic examination of the spleen revealed multiple granulomatous reaction. Numerous macrophages contained inclusions which were non-birefringent and non-staining with routine stains. Electron microscopy, scanning electron microscopy and energy dispersive X-Ray analysis were performed and revealed silicone. Its origin was silicone tubing of the hemodialysis equipment. Pathogenic effects of silicone are discussed.

摘要

一名67岁的慢性肾衰竭女性，定期进行血液透析，出现了与脾隔离相关的溶血性贫血。脾脏的光镜检查显示有多个肉芽肿反应。许多巨噬细胞含有内含物，这些内含物无双折射现象，用常规染色法不着色。进行了电子显微镜、扫描电子显微镜和能量色散X射线分析，结果显示为硅酮。其来源是血液透析设备的硅酮管。文中讨论了硅酮的致病作用。