Dammann H G, Müller P, Seitz H K, Simon B
Schweiz Med Wochenschr. 1983 Jun 18;113(24):895-8.
The effect of the substituted benzimidazole omeprazole on acid secretion after repeated administration to healthy volunteers has been studied. During repeated dosage of 30 mg once daily inhibition of basal and pentagastrin-stimulated acid output was increased from 30% after the first dose to about 60% after dose 4. The extent of inhibition did not further increase between day 5 and day 10. In four volunteers acid secretion returned to predose levels within 5 days after drug withdrawal. The 24-hour gastric acidity was reduced by about 72% and 82% after 9-day pretreatment with 30 mg and 60 mg omeprazole respectively. The antisecretory effect of omeprazole was independent of peak plasma concentrations. Omeprazole given once daily therefore possesses a long-lasting effect on gastric acid secretion, i.e. for more than 24 hours. This effect appears to be fully reversible since control levels of acid output are reached within 5 days.
已对健康志愿者重复给予取代苯并咪唑类药物奥美拉唑后其对胃酸分泌的影响进行了研究。在每日一次重复给予30mg剂量的过程中，基础胃酸分泌及五肽胃泌素刺激的胃酸分泌抑制率从首剂后的30%增加至第4剂后的约60%。第5天至第10天期间，抑制程度未进一步增加。4名志愿者在停药后5天内胃酸分泌恢复至给药前水平。分别用30mg和60mg奥美拉唑进行9天预处理后，24小时胃酸度分别降低约72%和82%。奥美拉唑的抑酸作用与血浆峰浓度无关。因此，每日一次给予奥美拉唑对胃酸分泌具有持久作用，即作用超过24小时。由于在5天内可达到胃酸分泌的对照水平，这种作用似乎是完全可逆的。
