Bradlow B A
S Afr Med J. 1983 Aug 27;64(9):313-6.
Oral anticoagulants were introduced into clinical practice in the late 1940s. An initial wave of enthusiasm was followed by a period of scepticism in the late 1950s and 1960s. During the 1970s and recently a number of studies have revealed new evidence of clinical benefits in many thrombo-embolic conditions. The importance of correct dosage based on sound laboratory control has been recognized as a fundamental prerequisite for efficient use of this form of therapy. A reassessment of the correct therapeutic range based on prothrombin assays which conform to an international standard has resulted in more effective dosage within acceptable limits of safety. Currently accepted indications for oral anticoagulation therapy and the optimal therapeutic ranges for various thromboplastin preparations are reviewed.
口服抗凝剂于20世纪40年代末被引入临床实践。最初的一阵热情之后，在20世纪50年代末和60年代迎来了一段怀疑期。在20世纪70年代以及最近，多项研究揭示了在许多血栓栓塞性疾病中临床获益的新证据。基于可靠实验室检测进行正确剂量调整的重要性，已被视为有效使用这种治疗方式的基本前提。基于符合国际标准的凝血酶原检测对正确治疗范围进行重新评估，已在可接受的安全限度内实现了更有效的剂量。本文对目前公认的口服抗凝治疗适应证以及各种凝血活酶制剂的最佳治疗范围进行了综述。
