Biemer J J
St. Joseph's Hospital, Tampa, FL 33607.
Ann Clin Lab Sci. 1988 Nov-Dec;18(6):421-8.
In an effort better to standardize the control of oral anticoagulant therapy, it has recently been recommended that the prothrombin time be reported in the form of an International Normalized Ratio (INR) based upon calibration of the locally employed thromboplastin with an International Reference Preparation. It has been demonstrated in our laboratory that the INR does minimize the differences in results which ensue from variations in the source of thromboplastin and instrumentation and should hopefully allow for better interlaboratory comparisons in the future. Recent studies have also suggested that many American patients tend to be over anticoagulated and at greater risk for hemorrhage. Based upon those findings, over 40 percent of our specimens were above the currently recommended levels.
为了更好地规范口服抗凝治疗的控制，最近有人建议，凝血酶原时间应以国际标准化比值（INR）的形式报告，该比值基于使用国际参考制剂对当地使用的凝血活酶进行校准。我们实验室已经证明，INR确实可以最大限度地减少因凝血活酶来源和仪器的差异而导致的结果差异，并有望在未来实现更好的实验室间比较。最近的研究还表明，许多美国患者往往抗凝过度，出血风险更高。基于这些发现，我们超过40%的样本高于目前推荐的水平。
