Fritsma G A
Am J Med Technol. 1983 Jun;49(6):453-6.
Vitamin E refers to a family of fat-soluble phenolic compounds called tocopherols, which have been established as essential nutrients in vertebrates. In animals the deficiency state has resulted in diminished reproductive capabilities, muscular dystrophy, exudative diathesis, megaloblastosis, gastrointestinal and pulmonary degeneration, and nephrosis. In humans with low vitamin E levels a subclinical diminished erythrocyte life-span has been demonstrated by hydrogen peroxide hemolysis test. This effect may have clinical significance among premature infants. The metabolic function of vitamin E appears to be as a scavenger of lipid peroxides and free oxygen radicals which enter into chain reactions to cause breakdown of lipids. Normal levels of the vitamin serve to prevent this cellular oxidative breakdown. Laboratory measurement of vitamin E is chromatographic, with HPLC presently used in both research and clinical applications. The association between vitamin E levels and hemolytic anemia in humans is currently under investigation.
维生素E是指一类名为生育酚的脂溶性酚类化合物，已被确认为脊椎动物必需的营养素。在动物中，缺乏维生素E会导致生殖能力下降、肌肉萎缩、渗出性素质、巨幼红细胞性贫血、胃肠道和肺部退化以及肾病。在维生素E水平较低的人类中，通过过氧化氢溶血试验已证明存在亚临床红细胞寿命缩短的情况。这种影响在早产儿中可能具有临床意义。维生素E的代谢功能似乎是作为脂质过氧化物和游离氧自由基的清除剂，这些物质会引发连锁反应导致脂质分解。正常水平的维生素可防止这种细胞氧化分解。维生素E的实验室测量采用色谱法，目前高效液相色谱法在研究和临床应用中均有使用。目前正在研究人类维生素E水平与溶血性贫血之间的关联。
