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Beta-cell tropin: synthesis and biological activity.

作者信息

Humphries J, Nurse E F, Dunmore S J, Beloff-Chain A, Taylor G W, Morris H R

出版信息

Biochem Biophys Res Commun. 1983 Jul 29;114(2):763-6. doi: 10.1016/0006-291x(83)90846-x.

DOI:10.1016/0006-291x(83)90846-x
PMID:6349635
Abstract

The structure of beta-cell tropin, an insulin secretagogue released by the neuro-intermediate lobe of the obese (ob/ob) mouse, has recently been determined as the 22-39 moiety of ACTH. A method for the preparation of this octadecapeptide using mild solid-phase procedures followed by preparative high pressure liquid chromatography is described. The molecular weight of the synthetic peptide has been confirmed by Fast Atom Bombardment mass spectrometry. Synthetic beta-cell tropin is indistinguishable in its chromatographic, antigenic and biological properties from natural beta-cell tropin.

摘要

相似文献

1
Beta-cell tropin: synthesis and biological activity.
Biochem Biophys Res Commun. 1983 Jul 29;114(2):763-6. doi: 10.1016/0006-291x(83)90846-x.
2
Evidence that the insulin secretagogue, beta-cell-tropin, is ACTH22-39.
Nature. 1983 Jan 20;301(5897):255-8. doi: 10.1038/301255a0.
3
beta-cell tropin, a peptide of the pituitary pars intermedia which stimulates insulin release.β细胞促生素，一种垂体中间部的肽，可刺激胰岛素释放。
FEBS Lett. 1980 Aug 11;117(1):303-7. doi: 10.1016/0014-5793(80)80967-7.
4
The characterization of beta-cell-tropin and its relation to hyperinsulinaemia in obesity.β细胞促生素的特性及其与肥胖症中高胰岛素血症的关系。
Biochem Soc Trans. 1981 Dec;9(6):522-3. doi: 10.1042/bst0090522.
5
Action of beta-cell tropin on insulin secretion in vivo and on lipid synthesis.β细胞促生素对体内胰岛素分泌及脂质合成的作用。
FEBS Lett. 1982 Mar 22;139(2):230-2. doi: 10.1016/0014-5793(82)80858-2.
6
Identification of beta-cell-trophin, a peptide of the pituitary pars intermedia which stimulates insulin secretion in plasma from genetically obese (ob/ob) mice.
J Endocrinol. 1982 Jul;94(1):125-30. doi: 10.1677/joe.0.0940125.
7
The insulin-like action of beta-cell-tropin on glucose and lipid metabolism in adipocytes.
Horm Metab Res. 1984 Dec;16 Suppl 1:55-8. doi: 10.1055/s-2007-1014898.
8
Studies on insulin secretion and the pituitary insulin secretagogue beta-cell-tropin in the sand-rat (Psammomys obesus).
Int J Obes. 1987;11(1):9-18.
9
Elevated plasma concentrations of beta-cell tropin (ACTH22-39) in diet-treated type II diabetic patients.饮食治疗的II型糖尿病患者血浆中β细胞促生素（促肾上腺皮质激素22 - 39）浓度升高。
Diabetes. 1992 Sep;41(9):1160-4. doi: 10.2337/diab.41.9.1160.
10
Evidence for the presence of the pituitary insulin secretagogue beta-cell trophin in human plasma.
J Endocrinol. 1986 Aug;110(2):303-7. doi: 10.1677/joe.0.1100303.

引用本文的文献

1
The effects of structural modifications on the insulin-releasing activity of beta-cell-tropin.结构修饰对β细胞促生长素胰岛素释放活性的影响。
Biochem J. 1987 Jun 15;244(3):797-800. doi: 10.1042/bj2440797.