The effects of structural modifications on the insulin-releasing activity of beta-cell-tropin.
作者信息
Dunmore S J, Panico M, Etienne A T, Morris H R, Beloff-Chain A
机构信息
Department of Biochemistry, Imperial College, London, U.K.
出版信息
Biochem J. 1987 Jun 15;244(3):797-800. doi: 10.1042/bj2440797.
Abstract
The minimal effective concentration of the pituitary insulin secretagogue beta-cell-tropin (beta-CT) on the in vitro perfused pancreas was established and the effects of various modifications of the peptide on its potency were tested: iodination with 127I and acetylation reduced the insulin-releasing activity of beta-cell-tropin, and the C-terminal fragments beta-CT-(2-18), beta-CT-(3-18) and beta-CT-(6-18) were all less potent than the intact molecule; beta-CT-(1-6) was not active and did not inhibit beta-CT-induced insulin release.
摘要
相似文献
1
The effects of structural modifications on the insulin-releasing activity of beta-cell-tropin.
Biochem J. 1987 Jun 15;244(3):797-800. doi: 10.1042/bj2440797.
2
3
The insulin-like action of beta-cell-tropin on glucose and lipid metabolism in adipocytes.
Horm Metab Res. 1984 Dec;16 Suppl 1:55-8. doi: 10.1055/s-2007-1014898.
4
Beta-cell tropin- and glucose-induced hypersecretion of insulin and amylin from perfused fatty rat pancreas.
J Endocrinol. 1993 Jun;137(3):375-81. doi: 10.1677/joe.0.1370375.
5
Evidence that the insulin secretagogue, beta-cell-tropin, is ACTH22-39.
Nature. 1983 Jan 20;301(5897):255-8. doi: 10.1038/301255a0.
6
Beta-cell-tropin is associated with short-term stimulation of food intake in chicks.β细胞促生素与雏鸡短期摄食刺激有关。
Gen Comp Endocrinol. 2015 Dec 1;224:278-82. doi: 10.1016/j.ygcen.2015.08.004. Epub 2015 Aug 4.
7
Beta-cell tropin: synthesis and biological activity.
Biochem Biophys Res Commun. 1983 Jul 29;114(2):763-6. doi: 10.1016/0006-291x(83)90846-x.
8
Evidence for the presence of the pituitary insulin secretagogue beta-cell trophin in human plasma.
J Endocrinol. 1986 Aug;110(2):303-7. doi: 10.1677/joe.0.1100303.
9
The effects of insulin and the pituitary peptide beta-cell tropin on the incorporation of D-3-3H-glucose into lipid in brown adipocytes from lactating and non-lactating rats.胰岛素和垂体肽β细胞促生素对泌乳和非泌乳大鼠棕色脂肪细胞中D-3-3H-葡萄糖掺入脂质的影响。
Biochem Biophys Res Commun. 1991 Dec 31;181(3):1437-41. doi: 10.1016/0006-291x(91)92100-x.
10
Correlation between plasma beta-cell tropin concentrations and body weight in obese rhesus monkeys.肥胖恒河猴血浆β细胞促生素浓度与体重之间的相关性。
Am J Physiol. 1992 Jun;262(6 Pt 1):E963-7. doi: 10.1152/ajpendo.1992.262.6.E963.
引用本文的文献
1
Post-translational modifications of pancreatic fluid proteins collected via the endoscopic pancreatic function test (ePFT).经内镜胰液功能试验 (ePFT) 收集的胰液蛋白的翻译后修饰。
J Proteomics. 2013 Oct 30;92:216-27. doi: 10.1016/j.jprot.2013.01.033. Epub 2013 Mar 14.
本文引用的文献
1
Preparation of iodine-131 labelled human growth hormone of high specific activity.高比活度碘-131标记人生长激素的制备
Nature. 1962 May 5;194:495-6. doi: 10.1038/194495a0.
2
A rapid and specific method for the high resolution purification and characterization of neuropeptides.一种用于神经肽高分辨率纯化和表征的快速且特异的方法。
J Neurochem. 1980 Mar;34(3):574-82. doi: 10.1111/j.1471-4159.1980.tb11183.x.
3
Fast atom bombardment: a new mass spectrometric method for peptide sequence analysis.快原子轰击：一种用于肽序列分析的新质谱方法。
Biochem Biophys Res Commun. 1981 Jul 30;101(2):623-31. doi: 10.1016/0006-291x(81)91304-8.
4
Identification of beta-cell-trophin, a peptide of the pituitary pars intermedia which stimulates insulin secretion in plasma from genetically obese (ob/ob) mice.
J Endocrinol. 1982 Jul;94(1):125-30. doi: 10.1677/joe.0.0940125.
5
Insulin release from the perfused rat pancreas, stimulated by perifusates of the pituitary neurointermediate lobes of genetically obese and lean mice.
J Endocrinol. 1982 Jan;92(1):15-21. doi: 10.1677/joe.0.0920015.
6
The characterization of beta-cell-tropin and its relation to hyperinsulinaemia in obesity.
Biochem Soc Trans. 1981 Dec;9(6):522-3. doi: 10.1042/bst0090522.
7
beta-cell tropin, a peptide of the pituitary pars intermedia which stimulates insulin release.β细胞促生素，一种垂体中间部的肽，可刺激胰岛素释放。
FEBS Lett. 1980 Aug 11;117(1):303-7. doi: 10.1016/0014-5793(80)80967-7.
8
Three types of alpha-melanocyte-stimulating hormone: bioactivities and half-lives.三种α-黑素细胞刺激素：生物活性与半衰期
Am J Physiol. 1983 Jul;245(1):E47-54. doi: 10.1152/ajpendo.1983.245.1.E47.
9
Beta-cell tropin: synthesis and biological activity.
Biochem Biophys Res Commun. 1983 Jul 29;114(2):763-6. doi: 10.1016/0006-291x(83)90846-x.
10
Evidence that the insulin secretagogue, beta-cell-tropin, is ACTH22-39.
Nature. 1983 Jan 20;301(5897):255-8. doi: 10.1038/301255a0.
Zotero 插件