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The effects of structural modifications on the insulin-releasing activity of beta-cell-tropin.结构修饰对β细胞促生长素胰岛素释放活性的影响。
Biochem J. 1987 Jun 15;244(3):797-800. doi: 10.1042/bj2440797.
2
Studies on insulin secretion and the pituitary insulin secretagogue beta-cell-tropin in the sand-rat (Psammomys obesus).
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Beta-cell tropin- and glucose-induced hypersecretion of insulin and amylin from perfused fatty rat pancreas.
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本文引用的文献

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Preparation of iodine-131 labelled human growth hormone of high specific activity.高比活度碘-131标记人生长激素的制备
Nature. 1962 May 5;194:495-6. doi: 10.1038/194495a0.
2
A rapid and specific method for the high resolution purification and characterization of neuropeptides.一种用于神经肽高分辨率纯化和表征的快速且特异的方法。
J Neurochem. 1980 Mar;34(3):574-82. doi: 10.1111/j.1471-4159.1980.tb11183.x.
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Fast atom bombardment: a new mass spectrometric method for peptide sequence analysis.快原子轰击：一种用于肽序列分析的新质谱方法。
Biochem Biophys Res Commun. 1981 Jul 30;101(2):623-31. doi: 10.1016/0006-291x(81)91304-8.
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Identification of beta-cell-trophin, a peptide of the pituitary pars intermedia which stimulates insulin secretion in plasma from genetically obese (ob/ob) mice.
J Endocrinol. 1982 Jul;94(1):125-30. doi: 10.1677/joe.0.0940125.
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Insulin release from the perfused rat pancreas, stimulated by perifusates of the pituitary neurointermediate lobes of genetically obese and lean mice.
J Endocrinol. 1982 Jan;92(1):15-21. doi: 10.1677/joe.0.0920015.
6
The characterization of beta-cell-tropin and its relation to hyperinsulinaemia in obesity.β细胞促生素的特性及其与肥胖症中高胰岛素血症的关系。
Biochem Soc Trans. 1981 Dec;9(6):522-3. doi: 10.1042/bst0090522.
7
beta-cell tropin, a peptide of the pituitary pars intermedia which stimulates insulin release.β细胞促生素，一种垂体中间部的肽，可刺激胰岛素释放。
FEBS Lett. 1980 Aug 11;117(1):303-7. doi: 10.1016/0014-5793(80)80967-7.
8
Three types of alpha-melanocyte-stimulating hormone: bioactivities and half-lives.三种α-黑素细胞刺激素：生物活性与半衰期
Am J Physiol. 1983 Jul;245(1):E47-54. doi: 10.1152/ajpendo.1983.245.1.E47.
9
Beta-cell tropin: synthesis and biological activity.
Biochem Biophys Res Commun. 1983 Jul 29;114(2):763-6. doi: 10.1016/0006-291x(83)90846-x.
10
Evidence that the insulin secretagogue, beta-cell-tropin, is ACTH22-39.
Nature. 1983 Jan 20;301(5897):255-8. doi: 10.1038/301255a0.

结构修饰对β细胞促生长素胰岛素释放活性的影响。

The effects of structural modifications on the insulin-releasing activity of beta-cell-tropin.

作者信息

Dunmore S J, Panico M, Etienne A T, Morris H R, Beloff-Chain A

机构信息

Department of Biochemistry, Imperial College, London, U.K.

出版信息

Biochem J. 1987 Jun 15;244(3):797-800. doi: 10.1042/bj2440797.

DOI:10.1042/bj2440797
PMID:2833221
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1148067/
Abstract

The minimal effective concentration of the pituitary insulin secretagogue beta-cell-tropin (beta-CT) on the in vitro perfused pancreas was established and the effects of various modifications of the peptide on its potency were tested: iodination with 127I and acetylation reduced the insulin-releasing activity of beta-cell-tropin, and the C-terminal fragments beta-CT-(2-18), beta-CT-(3-18) and beta-CT-(6-18) were all less potent than the intact molecule; beta-CT-(1-6) was not active and did not inhibit beta-CT-induced insulin release.

摘要

确定了垂体胰岛素分泌促进剂β细胞促生素（β-CT）在体外灌注胰腺上的最小有效浓度，并测试了该肽的各种修饰对其效力的影响：用127I进行碘化和乙酰化降低了β细胞促生素的胰岛素释放活性，并且C末端片段β-CT-(2-18)、β-CT-(3-18)和β-CT-(6-18)的效力均低于完整分子；β-CT-(1-6)无活性，且不抑制β-CT诱导的胰岛素释放。