Hoffmann J J, Thien T, van T'Laar A
Br J Clin Pharmacol. 1983 Jul;16(1):39-44. doi: 10.1111/j.1365-2125.1983.tb02141.x.
The effects of endralazine, administered intravenously, on blood pressure, heart rate, forearm blood flow, plasma renin activity, aldosterone, adrenaline and noradrenaline were studied in five patients with essential hypertension. Endralazine reduced peripheral vascular resistance, resulting in decrease in mean arterial pressure from 141 to 116 mm Hg and increase in heart rate from 67 to 92 beats/min. Plasma renin activity, adrenaline and noradrenaline increased significantly after endralazine infusion. All effects observed are consistent with endralazine acting as a peripheral vasodilating drug.
在5例原发性高血压患者中研究了静脉注射恩屈嗪对血压、心率、前臂血流量、血浆肾素活性、醛固酮、肾上腺素和去甲肾上腺素的影响。恩屈嗪降低外周血管阻力，导致平均动脉压从141毫米汞柱降至116毫米汞柱，心率从67次/分钟增至92次/分钟。静脉输注恩屈嗪后，血浆肾素活性、肾上腺素和去甲肾上腺素显著增加。观察到的所有效应均与恩屈嗪作为一种外周血管扩张药物的作用一致。
