结节性硬化症中的胶质纤维酸性蛋白

Glial fibrillary acidic protein in tuberous sclerosis.

作者信息

Tobo M, Mitsuyama Y, Kaku T

出版信息

Folia Psychiatr Neurol Jpn. 1983;37(1):95-100. doi: 10.1111/j.1440-1819.1983.tb00307.x.

DOI:10.1111/j.1440-1819.1983.tb00307.x

Abstract

We examined two cases of tuberous sclerosis for the presence of glial fibrillary acidic protein (GFAP) using the immunoperoxidase technique. The majority of abnormal giant cells in the cerebral cortex showed no reaction to anti-GFAP. Some abnormal cells in the cortical tuber and white matter showed a weak positive reaction. All of the subependymal tumor cells showed no GFAP in their cytoplasm. The abnormal giant cells in tuberous sclerosis, morphologically similar to gemistocytic astrocyte, are not accompanied by antigenic properties of GFAP.

摘要

我们采用免疫过氧化物酶技术检查了2例结节性硬化症病例，以检测胶质纤维酸性蛋白（GFAP）的存在情况。大脑皮质中的大多数异常巨细胞对抗GFAP无反应。皮质结节和白质中的一些异常细胞呈弱阳性反应。所有室管膜下肿瘤细胞的细胞质中均未显示GFAP。结节性硬化症中的异常巨细胞在形态上类似于肥胖型星形胶质细胞，但不具有GFAP的抗原特性。