Stefansson K, Wollmann R
Acta Neuropathol. 1980;52(2):135-40. doi: 10.1007/BF00688011.
The distribution of glial fibrillary acidic protein (GFAP) in the central nervous system (CNS) lesions of tuberous sclerosis (TS) was examined using antiserum against GFAP and the peroxidase antiperoxidase method of Sternberger. In cortical tubers there were islands of gemistocytic astrocytes staining intensely for GFAP and occasional giant cells having some cytoplasmic staining. The majority of the cortical giant cells had no GFAP. The islands were separated by areas devoid of astrocytes with perikaryal staining. A faintly staining fibrous network was found between these islands. The majority of cells in the subependymal nodules stained. The retinal phakoma stained but not as intensely as the subependymal nodules. There was no staining whatsoever in the giant cell subependymal tumors. Absence of GFAP staining in the subependymal giant cell tumors makes their classification as astrocytomas less certain.
采用抗胶质纤维酸性蛋白（GFAP）抗血清及Sternberger的过氧化物酶抗过氧化物酶方法，检测了结节性硬化症（TS）中枢神经系统（CNS）病变中GFAP的分布。在皮质结节中，有密集染色的肥胖型星形胶质细胞岛，偶尔可见有一些胞质染色的巨细胞。大多数皮质巨细胞无GFAP。这些岛被无核周染色的星形胶质细胞区域分隔开。在这些岛之间发现了一个淡染色的纤维网络。室管膜下结节中的大多数细胞染色。视网膜错构瘤染色，但不如室管膜下结节染色强烈。室管膜下巨细胞肿瘤无染色。室管膜下巨细胞肿瘤中GFAP染色缺失，使得将其归类为星形细胞瘤的确定性降低。
