Bainbridge D R
Immunol Rev. 1983;73:5-34. doi: 10.1111/j.1600-065x.1983.tb01076.x.
Two major classes of response to allogeneic lymphocytes can be detected in mice in vivo, based on injecting them intravenously with 51Cr-labelled lymph node cells and examining them in a short term assay. A natural immunity discriminating between allogeneic and syngeneic lymphocytes is seen in the lymph nodes (and to a lesser extent, the spleen), which has such close similarities to natural cell-mediated responses of the NK class as thymic-independence and radioresistance. However, it has immunological specificity of a conventional kind, probably towards serologically determined K/D antigens. There is also an active immune response, produced by immunisation with dissociated lymphoid cells or allografting, which consists of three elements: an IgG opsonising alloantibody response, diverting circulating lymphocytes to the liver; an IgM opsonin, localising them to the spleen; and a cell-mediated serum-dependent elimination mechanism that destroys cells entering the lymph nodes and spleen. Dose-response curves for the primary response show evidence of high-dose paralysis of elimination. Dose-time-response results for the secondary show a variety of unique characteristics; evidence is presented to suggest that several aspects of the phenomenon betray primitive features retained from an earlier stage in the evolution of the immunological system.
通过给小鼠静脉注射51Cr标记的淋巴结细胞并在短期试验中对其进行检测，可在体内检测到小鼠对同种异体淋巴细胞的两种主要反应类型。在淋巴结（在较小程度上也包括脾脏）中可观察到一种区分同种异体和同基因淋巴细胞的天然免疫，它与NK类的天然细胞介导反应有诸多相似之处，如胸腺非依赖性和放射抗性。然而，它具有传统类型的免疫特异性，可能针对血清学确定的K/D抗原。还存在一种由解离的淋巴细胞免疫或同种异体移植产生的主动免疫反应，它由三个要素组成：一种使同种异体抗体产生调理作用的IgG反应，将循环淋巴细胞导向肝脏；一种IgM调理素，将它们定位于脾脏；以及一种细胞介导的血清依赖性清除机制，可破坏进入淋巴结和脾脏的细胞。初次反应的剂量反应曲线显示出高剂量消除麻痹的证据。二次反应的剂量-时间反应结果显示出多种独特特征；有证据表明，该现象的几个方面显示出免疫系统进化早期阶段保留的原始特征。
