Lin M T, Ho L T, Uang W N
J Steroid Biochem. 1983 Jul;19(1B):433-8. doi: 10.1016/0022-4731(83)90200-5.
The effects of direct administration of TRH, TSH, LHRH, LH, ACTH, GH, FSH and prolactin into cerebral ventricle system on metabolic, respiratory, cardiovascular and behavioral responses were assessed in unanesthetized rats, Intraventricular administration of TRH, TSH, LHRH or LH caused hypothermia, decreased metabolism and/or cutaneous vasodilation at room temperature (22 degrees C). Intraventricular administration of FSH, ACTH or prolactin caused hyperthermia, increased metabolism and/or cutaneous vasoconstriction. Intraventricular administration of GH caused an insignificant change in thermoregulatory responses. There was no change in respiratory evaporative heat loss in response to either of the drugs tested. In addition, intraventricular administration of TRH, LHRH or LH caused tachycardia, hypertension and a reduction in the epinephrine-induced reflex bradycardia. In contrast, intraventricular administration of prolactin caused bradycardia, hypotension and an enhancement in the epinephrine-induced reflex bradycardia in conscious rats. There was no change in cardiovascular function in response to intraventricular administration of TSH, FSH, ACTH or GH. Furthermore, following intraventricular administration of TRH, but not TSH, LHRH, LH, FSH, GH, ACTH or prolactin three main categories of behavior were provoked: activity of normal type--forward locomotion stimulation, head and body rearing; stereotype activity--increased grooming and head swaying; and abnormal type behavior--tail elevation and piloerection in rats. The data indicate that most of the anterior pituitary hormones and their releasing hormones act through a central mechanism to influence physiological and/or behavioral functions.
在未麻醉的大鼠中，评估了将促甲状腺激素释放激素（TRH）、促甲状腺激素（TSH）、促黄体生成素释放激素（LHRH）、促黄体生成素（LH）、促肾上腺皮质激素（ACTH）、生长激素（GH）、促卵泡激素（FSH）和催乳素直接注入脑室系统对代谢、呼吸、心血管和行为反应的影响。在室温（22摄氏度）下，向脑室内注入TRH、TSH、LHRH或LH会导致体温过低、代谢降低和/或皮肤血管舒张。向脑室内注入FSH、ACTH或催乳素会导致体温过高、代谢增加和/或皮肤血管收缩。向脑室内注入GH对体温调节反应的影响不显著。所测试的任何一种药物都不会引起呼吸蒸发热损失的变化。此外，向脑室内注入TRH、LHRH或LH会导致心动过速、高血压，并减弱肾上腺素引起的反射性心动过缓。相比之下，向脑室内注入催乳素会导致清醒大鼠心动过缓、低血压，并增强肾上腺素引起的反射性心动过缓。向脑室内注入TSH、FSH、ACTH或GH对心血管功能没有影响。此外，向脑室内注入TRH（而非TSH、LHRH、LH、FSH、GH、ACTH或催乳素）后，会引发三类主要行为：正常类型的活动——向前运动刺激、头部和身体抬起；刻板行为——梳理毛发和头部摆动增加；以及异常类型的行为——大鼠尾巴抬起和竖毛。数据表明，大多数垂体前叶激素及其释放激素通过中枢机制发挥作用，以影响生理和/或行为功能。
