Lin M T, Chu P C, Leu S Y
Neuroendocrinology. 1983 Sep;37(3):206-11. doi: 10.1159/000123544.
The effects of administration of thyroid-stimulating hormone (TSH), thyrotropin-releasing hormone (TRH), luteinizing hormone (LH) or luteinizing hormone-releasing hormone (LHRH) into the lateral cerebral ventricle on thermoregulation and food and water intake were assessed in rats. Intracerebroventricular, but not intraperitoneal, injection of TSH, LH or LHRH produced hypothermia in rats at ambient temperatures of both 8 and 22 degrees C. The hypothermia in response to TSH injection was due to both decreased metabolic heat production and increased heat loss (cutaneous vasodilatation). The hypothermia in response to either LH or LHRH was due solely to decreased metabolic heat production. There was no change in respiratory evaporative heat loss in response to TSH, LH or LHRH injection. Furthermore, food but not water intake was greatly reduced following an intracerebroventricular injection of TSH or TRH in rats. On the other hand, intracerebroventricular administration of LH, but not LHRH, caused an increase in relative water intake (or water/food) in rats. However, intracerebroventricular administration of LH or LHRH had an insignificant effect on food intake. The data indicate that, in addition to their hormone actions, TSH, LH and their releasing hormones act through a central mechanism to influence some of the physiological or behavioral functions.
研究人员对大鼠侧脑室注射促甲状腺激素（TSH）、促甲状腺激素释放激素（TRH）、促黄体生成素（LH）或促黄体生成素释放激素（LHRH）后对体温调节、食物和水摄入量的影响进行了评估。在8摄氏度和22摄氏度的环境温度下，向大鼠侧脑室内注射TSH、LH或LHRH会导致体温过低，而腹腔注射则不会。注射TSH后引起的体温过低是由于代谢产热减少和散热增加（皮肤血管扩张）。注射LH或LHRH后引起的体温过低仅归因于代谢产热减少。注射TSH、LH或LHRH后呼吸蒸发散热没有变化。此外，向大鼠侧脑室内注射TSH或TRH后，食物摄入量大幅减少，但水摄入量没有变化。另一方面，向大鼠侧脑室内注射LH而非LHRH会导致相对水摄入量（或水/食物）增加。然而，向大鼠侧脑室内注射LH或LHRH对食物摄入量影响不大。数据表明，除了其激素作用外，TSH、LH及其释放激素还通过中枢机制影响某些生理或行为功能。
