芳基甲醇和缩氨基硫脲对疟原虫大分子合成及细胞稳定性的影响。
Arylmethanol and thiosemicarbazone influence of plasmodial macromolecular synthesis and cell stability.
作者信息
Emery C E, Stancato F A, Brown R E, Prichard D A, Wolfe A D
出版信息
Life Sci. 1983 Sep 26;33(13):1285-94. doi: 10.1016/0024-3205(83)90010-3.
PMID:6350781
Abstract
The influence of mefloquine and additional antimalarial drugs on (3H)adenosine uptake, macromolecular synthesis, and cell stability was determined in rodent red cells parasitized with Plasmodium berghei. High arylmethanol to cell ratios induced lysis, whereas inhibition of macromolecular synthesis occurred at lower drug/cell ratios. A 2-acetylpyridine thiosemicarbazone rapidly suppressed (3H)adenosine uptake, and also blocked macromolecular synthesis by parasitized cells.
摘要
测定了甲氟喹和其他抗疟药物对感染伯氏疟原虫的啮齿动物红细胞中（3H）腺苷摄取、大分子合成及细胞稳定性的影响。高芳基甲醇与细胞比例会诱导细胞裂解，而在较低药物/细胞比例时会发生大分子合成抑制。2-乙酰吡啶硫代半卡巴腙能迅速抑制（3H）腺苷摄取，也能阻断被寄生细胞的大分子合成。
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