Modnikov O P, Lomtev N G
Med Radiol (Mosk). 1983 Aug;28(8):37-40.
Insulin and C-peptide levels were studied with a radioimmunoassay in the peripheral blood serum of 44 patients with gastric and cervical cancer and 22 healthy persons. Hyperfunction of the pancreatic insular apparatus was shown in cancer patients which was expressed in a statistically significant increase in the C-peptide level. In gastric cancer patients hyperfunction of the insular apparatus was accompanied by hypoinsulinemia, and in cervical cancer patients by hormoinsulinemia. However an analysis has shown that the ratio insulin/C-peptide in gastric and cervical cancer patients was about the same and significantly lower than the control. A conclusion has been made that in spite of difference in the initial insulin concentration, the same phenomenon--acceleration of the metabolic clearance of insulin--occurs in patients with cancer of the above sites. As a result of treatment irrespective of its modality the reverse development of changes revealed before treatment took place. The C-peptide level decreased, the ratio insulin/C-peptide increased, i.e. hyperfunction of the insular apparatus disappeared and the metabolic clearance of insulin slowed down.
采用放射免疫分析法对44例胃癌和宫颈癌患者及22名健康人的外周血清中的胰岛素和C肽水平进行了研究。结果显示，癌症患者存在胰岛功能亢进，表现为C肽水平有统计学意义的升高。在胃癌患者中，胰岛功能亢进伴有低胰岛素血症，而在宫颈癌患者中则伴有高胰岛素血症。然而，分析表明，胃癌和宫颈癌患者的胰岛素/C肽比值大致相同，且显著低于对照组。得出的结论是，尽管初始胰岛素浓度存在差异，但上述部位癌症患者均出现了相同的现象——胰岛素代谢清除加速。无论采用何种治疗方式，治疗后均出现了治疗前所发现变化的逆向发展。C肽水平下降，胰岛素/C肽比值升高，即胰岛功能亢进消失，胰岛素代谢清除减慢。
