Pavelić K, Bolanca M, Vecek N, Pavelić J, Marotti T, Vuk-Pavlović S
J Natl Cancer Inst. 1982 Jun;68(6):891-4.
Inasmuch as the elevated levels of substance(s) immunologically cross-reactive with insulin (SICRI) in a diabetic woman with carcinoma of the corpus uteri decreased following the surgical removal of the uterus and ovaries, 80 women with cervical carcinomas of various stages and 70 women with carcinomas of the corpus uteri of various stages were screened for the levels of SICRI and C-peptide. The levels of SICRI in the second, third, and fourth stages of the cancers were elevated (up to six times above the normal levels of immunoreactive insulin) and stage-dependent. The levels of C-peptide, which are related to the insulin-secreting activity of pancreatic beta-cells, were normal and independent of the stage of cancer.
鉴于一名患有子宫体癌的糖尿病女性在手术切除子宫和卵巢后，与胰岛素发生免疫交叉反应的物质（SICRI）水平升高，对80名处于不同阶段的宫颈癌女性和70名处于不同阶段的子宫体癌女性进行了SICRI和C肽水平筛查。癌症第二、三、四阶段的SICRI水平升高（高达免疫反应性胰岛素正常水平的六倍）且与阶段相关。与胰腺β细胞胰岛素分泌活性相关的C肽水平正常，且与癌症阶段无关。
