[Interaction of insulin with receptors in insulin-independent diabetes mellitus].

Parameters of insulin binding with its specific receptors were determined in small concentrations of peripheral blood mononuclear cells. Examination of 22 patients has shown that the higher the level of insulinemia and the degree of obesity in the insulin-independent form of diabetes mellitus, the lower insulin binding. A decrease in the binding results from the reduction of the number of binding sites and partially from the affinity of type I receptors for insulin. Causes of a decrease in the number of receptors in patients with diabetes mellitus who are not suffering from obesity are discussed.