Gray R S, Elton R A, Clarke B F
Q J Med. 1983 Spring;52(206):244-55.
The prevalences of thyroid disease, insulin-dependent and non-insulin-dependent diabetes were compared in first degree relatives of diabetics with and without coexisting autoimmune thyroid disease. Thyroid disease was more common in siblings of diabetics with thyroid disease than in those of diabetics without thyroid disease. Insulin-dependent diabetes was more common in siblings of diabetics with a personal or family history of thyroid disease than in those of diabetics without such a history. The prevalence of non-insulin-dependent diabetes was unrelated to that of thyroid disease but was greater in siblings of non-insulin-dependent diabetics than in those of insulin-dependent diabetics. These findings add further support to the aetiological distinction between insulin-dependent and non-insulin-dependent diabetes and suggest that further heterogeneity exists within the population of insulin-dependent diabetics based on the presence of a personal or family history of thyroid disease.
对患有和未患有自身免疫性甲状腺疾病的糖尿病患者的一级亲属中甲状腺疾病、胰岛素依赖型糖尿病和非胰岛素依赖型糖尿病的患病率进行了比较。甲状腺疾病在患有甲状腺疾病的糖尿病患者的兄弟姐妹中比在未患有甲状腺疾病的糖尿病患者的兄弟姐妹中更常见。有个人或家族甲状腺疾病史的糖尿病患者的兄弟姐妹中，胰岛素依赖型糖尿病比无此类病史的糖尿病患者的兄弟姐妹中更常见。非胰岛素依赖型糖尿病的患病率与甲状腺疾病的患病率无关，但在非胰岛素依赖型糖尿病患者的兄弟姐妹中比在胰岛素依赖型糖尿病患者的兄弟姐妹中更高。这些发现进一步支持了胰岛素依赖型糖尿病和非胰岛素依赖型糖尿病在病因学上的区别，并表明基于个人或家族甲状腺疾病史的存在，胰岛素依赖型糖尿病患者群体中存在进一步的异质性。
