Chalkiadakis G, Kostakis A, Karayannacos P E, Giamarellou H, Dontas I, Sakellariou I, Skalkeas G D
Surg Gynecol Obstet. 1983 Sep;157(3):257-60.
The effect of heparin upon the clinical and pathologic course of experimentally induced peritonitis in the rat was studied. Peritonitis was induced in 40 rats by creating a closed ileal loop 4 centimeters long at a distance of 5 centimeters from the ileocecal valve. The rats were divided into two groups of 20 each. The first group served as the control group while each rat of the second group received 30 units of heparin subcutaneously per day postoperatively. Survival was drastically increased in the group receiving heparin (p = 0.001). Adhesion or abscess formation was considerably reduced in this group. The results of peritoneal cultures showed decreased incidence of Escherichia coli and clostridia in the heparin-treated group. Blood cultures also showed decreased incidence of both aerobes and anaerobes in the treated group. It is concluded from this that the administration of heparin significantly prolongs survival time of animals with peritonitis and reduces the development of adhesions and abscesses in the peritoneal cavity. This beneficial effect could be attributed to decreased fibrinogen deposits within the peritoneal cavity, thus rendering the bacteria more susceptible to cellular and noncellular clearing mechanisms.
研究了肝素对实验性诱导的大鼠腹膜炎临床和病理过程的影响。通过在距回盲瓣5厘米处制作一个4厘米长的闭合回肠袢，在40只大鼠中诱发腹膜炎。将大鼠分为两组，每组20只。第一组作为对照组，而第二组的每只大鼠在术后每天皮下注射30单位肝素。接受肝素治疗的组生存率显著提高（p = 0.001）。该组粘连或脓肿形成明显减少。腹膜培养结果显示，肝素治疗组大肠杆菌和梭菌的发生率降低。血培养也显示治疗组需氧菌和厌氧菌的发生率均降低。由此得出结论，肝素给药可显著延长腹膜炎动物的生存时间，并减少腹腔内粘连和脓肿的形成。这种有益效果可能归因于腹腔内纤维蛋白原沉积减少，从而使细菌更容易受到细胞和非细胞清除机制的作用。
