Gruchalla R S, Strome P G, Streilein J W
Transplantation. 1983 Sep;36(3):318-23. doi: 10.1097/00007890-198309000-00017.
Neonatally-induced tolerance of class I H-2 alloantigens can be abolished in adult, long-term-tolerant mice by infusions of immunocompetent cells from donors syngeneic with the recipient. By contrast, neonatally-induced tolerance of Ia alloantigens can not be abolished easily, indicating that the Ia-specific tolerant state is maintained by an active process that can be impressed upon mature alloreactive lymphoid cells in the tolerant environment. This finding is concordant with previous observations that tolerance of Ia alloantigens can readily be transferred adoptively by inoculating lymphoid cells from tolerant mice into syngeneic, naive recipients. It is concluded that class II H-2 antigens induce a type of unresponsiveness that class I antigens fail to evoke, an unresponsiveness that is actively maintained among mature immunocompetent cells. It is proposed that, in addition to a central process of clonal deletion/inactivation that both class I and class II H-2 antigens induce in neonatal mice, Ia alloantigens also evoke a secondary, fail-safe mechanism that operates to prevent alloreactivity from emerging when cells with alloreactive potential escape the central mechanism, or mutate to alloreactivity at a later stage of maturation.
新生期诱导的Ⅰ类H-2同种抗原耐受性，在成年长期耐受的小鼠中，可通过输注与受体同基因供体的免疫活性细胞而被消除。相比之下，新生期诱导的Ⅱ类抗原耐受性不易被消除，这表明Ⅱ类抗原特异性耐受状态是由一个活跃过程维持的，该过程可作用于耐受环境中的成熟同种反应性淋巴细胞。这一发现与先前的观察结果一致，即通过将耐受小鼠的淋巴细胞接种到同基因的未致敏受体中，Ⅱ类抗原耐受性很容易被过继转移。得出的结论是，Ⅱ类H-2抗原诱导了一种Ⅰ类抗原未能引发的无反应状态，这种无反应状态在成熟免疫活性细胞中被积极维持。有人提出，除了Ⅰ类和Ⅱ类H-2抗原在新生小鼠中诱导的克隆缺失/失活的中心过程外，Ⅱ类抗原还引发了一种次级的安全机制，当具有同种反应潜能的细胞逃脱中心机制或在成熟后期突变为同种反应性时，该机制可防止同种反应性出现。
