Saario I, Arvilommi H, Silvola H
Acta Chir Scand. 1983;149(4):423-6.
A study on 42 surgical patients was carried out to find out whether cefuroxime may be substituted for gentamicin in combination with metronidazole in the treatment of peritonitis secondary to perforation of appendix. All patients recovered and there were four wound infections in each group. Both aerobic and anaerobic bacteria were cultured in the peritoneal fluid in 69% of cases and anaerobes only in 19% of the patients. Postoperatively the patients were followed up for one month. The mean length of the hospital stay and convalescence did not differ significantly. There was also no difference in the time to the removal of gastric suction, laboratory measurements and the incidence of pyrexia between the study groups. Although the number of patients was limited the present study indicates that gentamicin may be replaced by less toxic cefuroxime. This is especially the case if there are several risk factors in the use of gentamicin and if there is not a possibility for monitoring the serum levels of gentamicin.
一项针对42名外科手术患者的研究开展，以确定在治疗阑尾穿孔继发腹膜炎时，头孢呋辛是否可替代庆大霉素与甲硝唑联合使用。所有患者均康复，每组有4例伤口感染。69%的病例腹膜液中培养出需氧菌和厌氧菌，仅19%的患者培养出厌氧菌。术后对患者进行了1个月的随访。平均住院时间和康复时间无显著差异。研究组之间在撤除胃管的时间、实验室检测结果以及发热发生率方面也无差异。尽管患者数量有限，但本研究表明毒性较小的头孢呋辛可替代庆大霉素。如果在使用庆大霉素时有多种危险因素，且无法监测庆大霉素的血清水平，情况尤其如此。
