Dantzler B S, Martin B G, Nelson H S
Ann Allergy. 1983 Sep;51(3):362-6.
The effect of prolonged exposure to either positive or negative small air ions was studied in nine patients with bronchial asthma, of whom seven had reported increased respiratory symptoms in association with weather changes. On consecutive days, while grounded, patients were exposed for six hours to approximately 10,000/cc of either positive or negative ions. Pulmonary function, pulse and blood pressure were measured throughout the exposure. Questionnaires to assess emotional state and physical symptoms were completed after 15 minutes and five hours each day. Urinary 5-hydroxy indoleacetic acid (5HIAA) excretion was measured. Patients were continued on theophylline but adrenergics and corticosteroids were withheld. No patient experienced an exacerbation of asthma. Symptoms, pulmonary function, pulse and blood pressure, urinary 5HIAA excretion and the response to the questionnaires did not differ significantly between the two ion exposures. Thus moderately long exposure to positive or negative small air ions did not influence the clinical condition of these patients, many of whom reported exacerbations with weather changes. The findings do not support a significant role of small air ions in exacerbations or treatment of bronchial asthma.
对9名支气管哮喘患者进行了研究，以探讨长期暴露于正性或负性小空气离子的影响，其中7名患者报告呼吸道症状会随天气变化而加重。在连续的日子里，患者在接地状态下，每天暴露于约10,000个/立方厘米的正离子或负离子环境中6小时。在整个暴露过程中测量肺功能、脉搏和血压。每天在15分钟和5小时后完成评估情绪状态和身体症状的问卷调查。测量尿5-羟吲哚乙酸（5HIAA）排泄量。患者继续服用茶碱，但停用肾上腺素能药物和皮质类固醇。没有患者哮喘发作加剧。两种离子暴露之间，症状、肺功能、脉搏和血压、尿5HIAA排泄量以及问卷调查的反应均无显著差异。因此，适度长时间暴露于正性或负性小空气离子对这些患者的临床状况没有影响，其中许多患者报告症状会随天气变化而加重。这些发现不支持小空气离子在支气管哮喘发作或治疗中起重要作用。
