Higgs C M, Laszlo G
Br J Dis Chest. 1983 Jul;77(3):262-9.
beta-Adrenergic bronchodilators can prevent the development of exercise-induced asthma (EIA). To investigate the duration of this effect, we determined the time at which the protective effect of salbutamol diminished significantly in six subjects. All had stable asthma known to be triggered by exercise. Following a control exercise test, identical tests were repeated weekly at various times (1-6 hours) after inhalation of 200 micrograms of salbutamol. Significant protection (less than 75%) was lost in two subjects at 2 hours, in two at 4 hours and in two at 6 hours. A further exercise test was performed after inhalation of 1 mg of reproterol, at the time when salbutamol no longer afforded significant protection. There was a significantly smaller fall in peak expiratory flow rate after exercise (P less than 0.01) with reproterol than with salbutamol, at the same time after inhalation. There was no relationship between the degree or duration of protection from EIA and the bronchodilator effect of the drugs, the age and sex of the subjects, the length of asthma history or severity of base-line EIA, except perhaps the requirement for regular treatment with a steroid aerosol or sodium cromoglycate.
β-肾上腺素能支气管扩张剂可预防运动诱发性哮喘（EIA）的发作。为了研究这种作用的持续时间，我们测定了6名受试者中沙丁胺醇的保护作用显著减弱的时间。所有受试者均患有已知由运动诱发的稳定型哮喘。在进行一次对照运动试验后，在吸入200微克沙丁胺醇后的不同时间（1 - 6小时）每周重复进行相同的试验。2小时后，两名受试者的显著保护作用（下降小于75%）消失；4小时后，另外两名受试者的显著保护作用消失；6小时后，又有两名受试者的显著保护作用消失。在沙丁胺醇不再提供显著保护作用时，吸入1毫克瑞普特罗后进行了进一步的运动试验。吸入后相同时间，使用瑞普特罗时运动后呼气峰值流速的下降显著小于使用沙丁胺醇时（P < 0.01）。除了可能需要使用类固醇气雾剂或色甘酸钠进行常规治疗外，对EIA的保护程度或持续时间与药物的支气管扩张作用、受试者的年龄和性别、哮喘病史的长短或基线EIA的严重程度之间没有关系。
