Goldenberg S L, Johnson H W, Ettinger S L, McLoughlin M G
Can J Surg. 1983 Sep;26(5):418-22.
Single-stage skin patch urethroplasty has become accepted therapy for urethral stricture. Review of the literature and the authors' experience indicated good short-term clinical results (80%), but the fate of the implanted tissue has not been well documented. Twenty-three skin and vein patch autograft repairs of defects created in the rabbit urethra were examined histologically after 4 weeks in situ. Two of 12 skin grafts remained intact while 9 of 11 vein patches were successful. The vein patch autograft appears to provide better support because of the survival of the elastic and smooth muscle tissues. Unlike skin grafts, which retain their squamous epithelium, the venous endothelium is entirely replaced by urothelium, thus decreasing potential neoplastic degeneration, and the incidence of fistula formation, fibrosis and chronic inflammation. Further investigation is required before introducing the vein patch urethroplasty into clinical practice.
单阶段皮肤补片尿道成形术已成为治疗尿道狭窄的公认疗法。文献回顾及作者的经验表明，该方法具有良好的短期临床效果（80%），但植入组织的转归情况尚无充分记录。对23例兔尿道缺损采用皮肤和静脉补片自体移植修复，原位放置4周后进行组织学检查。12例皮肤移植中有2例保持完整，而11例静脉补片中9例成功。静脉补片自体移植似乎能提供更好的支撑，因为弹性和肌肉组织得以存活。与保留鳞状上皮的皮肤移植不同，静脉内皮完全被尿路上皮取代，从而降低了潜在的肿瘤性退变以及瘘管形成、纤维化和慢性炎症的发生率。在将静脉补片尿道成形术引入临床实践之前，还需要进一步研究。
