Boulton Jones J M, Tulloch I, Dore B, McLay A
Clin Nephrol. 1983 Aug;20(2):72-7.
This study demonstrated that a soluble factor derived from patients with nephrotic syndrome caused changes consistent with the development of proteinuria when infused into the renal artery of a rat. The supernatants of cultures of stimulated lymphocytes of patients with the nephrotic syndrome containing autologous sera were infused into the renal arteries of rats and caused patchy spreading of the foot processes of epithelial cells and reduction of charge of the glomerular basement membrane of rat kidneys. The equivalent supernatants from normal subjects did not produce these changes.
本研究表明，将肾病综合征患者来源的一种可溶性因子注入大鼠肾动脉后，可引起与蛋白尿发生发展一致的变化。将含有自体血清的肾病综合征患者受刺激淋巴细胞培养上清液注入大鼠肾动脉，可导致大鼠肾脏上皮细胞足突片状扩展及肾小球基底膜电荷减少。正常受试者的等量上清液则不会产生这些变化。
