Mimran A, Zambrowski J J, Coppolani T
Curr Med Res Opin. 1983;8 Suppl 3:105-8. doi: 10.1185/03007998309109844.
The antihypertensive effect of indapamide (2.5 mg/day) was evaluated in 2184 patients with essential hypertension by 300 French general practitioners over a period of treatment of 3 months. Indapamide produced a significant reduction in blood pressure, the amplitude of which was directly related to pre-treatment blood pressure levels; normalization of blood pressure was achieved in approximately 66% of patients. Addition of a beta-blocker to the treatment regimen on the second month was required in only 10% of patients. No severe side-effect was reported, although a significant reduction in kalaemia was noted in less than 5% of patients.
300名法国全科医生对2184例原发性高血压患者进行了为期3个月的治疗，评估了吲达帕胺（2.5毫克/天）的降压效果。吲达帕胺使血压显著降低，其降幅与治疗前血压水平直接相关；约66%的患者血压恢复正常。仅10%的患者在第二个月需要在治疗方案中加用β受体阻滞剂。尽管不到5%的患者血钾显著降低，但未报告严重副作用。
