The antihypertensive action of indapamide: results of a French multicentre study of 2,184 ambulant patients.

A multicentre study was carried out by 300 French general practitioners to evaluate the efficacy and acceptability of indapamide in a single daily dose of 2.5 mg in 2,184 patients with essential hypertension. There was a significant reduction in blood pressure, 65.7% of the patients attaining a normal blood pressure. In addition, it was found that indapamide produced an excellent reduction in blood pressure in severely hypertensive patients, including those on combined therapy with a beta-blocker. The elderly patients were found to benefit from the simple dosage and the lack of side effects such as postural hypotension. There was little change in any of the biochemical measurements.