Coulter J B, Engelke J A, Eaton D K
Exp Eye Res. 1983 Aug;37(2):153-7. doi: 10.1016/0014-4835(83)90074-x.
Insulin concentrations were measured in the aqueous humors of insulin-treated and untreated diabetic rabbits. The aqueous humor insulin concentration of diabetic rabbits after feeding was less than that of normal control animals. When diabetic rabbits were treated with insulin, the aqueous humor insulin concentration rose to concentrations much greater than in normal ones. The aqueous: plasma concentration ratios of both insulin and total protein for diabetic animals were greater than those for normal ones and suggest that the permeability of the blood-aqueous barrier was greater in the diabetic rabbits. Since insulin is known to be capable of influencing the metabolism of the lens, it is conceivable that abnormal insulin concentrations in aqueous humor may influence the development of cataract in diabetes.
测量了胰岛素治疗和未治疗的糖尿病兔房水中的胰岛素浓度。喂食后糖尿病兔房水胰岛素浓度低于正常对照动物。当用胰岛素治疗糖尿病兔时，房水胰岛素浓度升至远高于正常兔的浓度。糖尿病动物胰岛素和总蛋白的房水：血浆浓度比均高于正常动物，提示糖尿病兔血-房水屏障的通透性更高。由于已知胰岛素能够影响晶状体的代谢，因此可以想象房水中异常的胰岛素浓度可能会影响糖尿病性白内障的发生。
