Bianco S, Robuschi M, Damonte C
Eur J Respir Dis Suppl. 1983;128 (Pt 1):213-21.
A new method of challenge with H2O is described after summarizing the results of previous studies concerning the pharmacological prevention of bronchoconstriction induced by PGF2 alpha and by ultrasonic mist of distilled water (H2O). This provides a simple, rapid and reproducible way of obtaining linear dose-response curves by plotting times of exposures against absolute or percent increases in sRaw. The preventive activity of several drugs against this type of bronchospasm has been tested. Beta 2-stimulants (fenoterol) were the most effective, both in terms of intensity and duration of action (more than 6 hours). DSCG, tiaramide and nifedipine were also efficient. Oxitropium bromide was almost ineffective, in spite of the comparatively high doses used. The H1 and H2 antihistamines chlorpheniramine and ranitidine were ineffective. The possible implications of these results are discussed, mainly in order to try to understand the mechanism of H2O bronchospasms, for which airways cooling does not seem at work.
在总结了先前有关药理学预防PGF2α和蒸馏水（H2O）超声雾化诱导的支气管收缩的研究结果后，描述了一种用H2O激发的新方法。这提供了一种简单、快速且可重复的方法，通过绘制暴露时间与sRaw的绝对增加量或百分比增加量的关系来获得线性剂量反应曲线。已经测试了几种药物对这种类型支气管痉挛的预防活性。β2激动剂（非诺特罗）在作用强度和持续时间方面（超过6小时）最为有效。色甘酸钠、噻拉米特和硝苯地平也有效。尽管使用了相对较高的剂量，氧托溴铵几乎无效。H1和H2抗组胺药氯苯那敏和雷尼替丁无效。讨论了这些结果可能的影响，主要是为了试图理解H2O支气管痉挛的机制，气道冷却似乎并非其作用机制。
