Solopov V N, Lunichkina I V
Klin Med (Mosk). 1991 Feb;69(2):55-8.
It is suggested to use alpha-stimulating effect of naphthyzine and halazoline for pharmacological spirometric testing in evaluating the inflammatory-edematous component of bronchial obstruction. These anti-edema agents combined with standard bronchospasmolytics (beta 2-agonists and cholinolytics) proved effective in arresting episodes of asphyxia. Optimal doses of naphthyzine and halazoline, related side effects have been clarified in case of their addition to selective beta 2-agonists, cholinolytics and combinations thereof. In contrast to nonselective adrenomimetic drugs adrenaline and ephedrine, naphthyzine, halazoline or similar medicines do not produce cardiostimulation this justifying their use in combination with selective bronchospasmolytic berotec, salbutamol , berodual and atrovent.
建议利用萘甲唑啉和哈唑啉的α刺激作用进行药理学肺活量测定试验，以评估支气管阻塞的炎症水肿成分。这些抗水肿药物与标准支气管解痉剂（β2激动剂和胆碱能阻滞剂）联合使用，已证明对窒息发作有效。萘甲唑啉和哈唑啉的最佳剂量以及将它们添加到选择性β2激动剂、胆碱能阻滞剂及其组合中时的相关副作用已得到明确。与非选择性拟肾上腺素药物肾上腺素和麻黄碱不同，萘甲唑啉、哈唑啉或类似药物不会产生心脏刺激作用，这证明它们可与选择性支气管解痉剂倍氯米松、沙丁胺醇、溴化异丙托品和异丙阿托品联合使用。
