Wardle J K, Snow M H, Ingham H R, Selkon J B
J Antimicrob Chemother. 1983 Jul;12 Suppl A:389-93. doi: 10.1093/jac/12.suppl_a.389.
An open study of the use of ceftazidime in patients with Gram-negative infections was undertaken in a district general hospital. Ceftazidime was used in three groups of patients: 17 adults with infections due to Pseudomonas sp. or multi-resistant enterobacteria, three children with cystic fibrosis who had chest infections, and two premature neonates with severe pseudomonal pneumonia. The infections in the adult group included respiratory tract (6), urinary tract (4), wound infection (3), abdominal sepsis (2), osteomyelitis and panophthalmitis. In this group, ceftazidime was given as 1-2 g tid intravenously. In three patients, gentamicin was used concurrently and in four metronidazole was added. 76% of the adult group achieved complete clinical cure, all three cystic fibrosis cases improved markedly, and the two neonates showed complete resolution of the pneumonia. No adverse biochemical or haematological side effects occurred, although one patient developed an urticarial skin rash on the last day of a ten-day treatment course which resolved after discontinuing the ceftazidime.
在一家地区综合医院对头孢他啶用于革兰氏阴性菌感染患者进行了一项开放性研究。头孢他啶应用于三组患者：17例因假单胞菌属或多重耐药肠杆菌感染的成年人、3例患有胸部感染的囊性纤维化儿童以及2例患有严重铜绿假单胞菌肺炎的早产儿。成年组的感染包括呼吸道感染（6例）、泌尿道感染（4例）、伤口感染（3例）、腹部脓毒症（2例）、骨髓炎和全眼球炎。在该组中，头孢他啶以1 - 2克每日三次静脉给药。3例患者同时使用了庆大霉素，4例加用了甲硝唑。成年组76%的患者实现了临床完全治愈，所有3例囊性纤维化病例均明显改善，2例新生儿的肺炎完全消退。未出现不良生化或血液学副作用，尽管1例患者在为期10天的治疗疗程的最后一天出现了荨麻疹皮疹，在停用头孢他啶后皮疹消退。
