Maslow M J, Rosenberg A, Pollock A A, Press R A, Silverman D, El-Sadr W, Richmond A S, Simberkoff M S, Rahal J J
J Antimicrob Chemother. 1983 Jul;12 Suppl A:213-7. doi: 10.1093/jac/12.suppl_a.213.
Sixteen patients with serious Gram-negative bacillary infections were treated with intravenous ceftazidime, 2 g every 8 h. The majority of patients had bacteraemia or pneumonitis or both. Ten patients were cured and six improved. Seven of ten patients infected with Pseudomonas aeruginosa were cured, and three improved. No adverse reactions occurred. Four strains of Ps. aeruginosa became resistant to ceftazidime in patients who were cured or improved clinically. Ceftazidime is effective as single drug therapy for serious Gram-negative infections, including those due to Ps. aeruginosa.
16例严重革兰氏阴性杆菌感染患者接受了静脉注射头孢他啶治疗，每8小时2克。大多数患者患有菌血症或肺炎或两者兼有。10例患者治愈，6例病情改善。10例铜绿假单胞菌感染患者中，7例治愈，3例病情改善。未发生不良反应。在临床治愈或病情改善的患者中，有4株铜绿假单胞菌对头孢他啶产生了耐药性。头孢他啶作为单一药物治疗严重革兰氏阴性菌感染有效，包括由铜绿假单胞菌引起的感染。
