甲氧苄啶-磺胺甲恶唑联合用药对耐甲氧西林金黄色葡萄球菌临床分离株的体外和体内疗效
In vitro and in vivo efficacy of the combination trimethoprim-sulfamethoxazole against clinical isolates of methicillin-resistant Staphylococcus aureus.
作者信息
Elwell L P, Wilson H R, Knick V B, Keith B R
出版信息
Antimicrob Agents Chemother. 1986 Jun;29(6):1092-4. doi: 10.1128/AAC.29.6.1092.
Abstract
The in vitro susceptibilities of 16 independent, geographically distinct clinical isolates of methicillin-resistant Staphylococcus aureus to trimethoprim (TMP) in combination with sulfamethoxazole (SMX) were evaluated. Although methicillin-resistant S. aureus strains appear to be universally resistant to SMX, the combination TMP-SMX was found to be synergistic in vitro (in combination, the MICs of both drugs decreased 6- to 25-fold) as well as in vivo (5- to 6-fold reduction in TMP at 50% effective doses).
摘要
对16株独立的、来自不同地理区域的耐甲氧西林金黄色葡萄球菌临床分离株进行了体外试验，以评估其对甲氧苄啶（TMP）联合磺胺甲恶唑（SMX）的敏感性。尽管耐甲氧西林金黄色葡萄球菌菌株似乎对SMX普遍耐药，但发现TMP-SMX联合用药在体外（联合使用时，两种药物的最低抑菌浓度均降低了6至25倍）以及体内（50%有效剂量时TMP降低了5至6倍）均具有协同作用。
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