Lopitaux R, Sirot J, Epifanie J L, Rampon S, Cluzel R
Pathol Biol (Paris). 1983 May;31(5):442-5.
Rifampicin is used for treating 20 Staphylococcus septic arthritis, in combination with another antibiotic. The former is chosen for its striking bone diffusion. The average duration of the whole antibiotic treatment is 3 months. Rifampicin is usually prescribed, in daily doses of 1 200 mg for 60 days, after one month of parenteral antibiotherapy. The bactericidal activity is controlled regularly by measuring serum inhibitory titre. For 2 patients, the administration of rifampicin is suspended after 12 and 25 days respectively, due to digestive disorders. Results are evaluated at the end of a period averaging 18 months. Articular infection has been cured in all patients. Taking these results into account, we are able to emphasize that the inclusion of rifampicin in the antibiotic scheme is of great value in treating bone and articular infections.
利福平与另一种抗生素联合用于治疗20例葡萄球菌性化脓性关节炎。选用利福平是因其显著的骨扩散性。整个抗生素治疗的平均持续时间为3个月。在进行1个月的胃肠外抗生素治疗后，利福平通常按每日1200毫克的剂量给药，持续60天。通过测量血清抑制滴度定期控制杀菌活性。有2例患者分别在12天和25天后因消化系统紊乱而暂停使用利福平。在平均18个月的时间段结束时评估结果。所有患者的关节感染均已治愈。考虑到这些结果，我们能够强调在抗生素方案中加入利福平在治疗骨和关节感染方面具有重要价值。
