Grosset J, Truffot-Pernot C, Lecoeur H, Guelpa-Lauras C C
Pathol Biol (Paris). 1983 May;31(5):446-50.
Intermittent regimens with rifampicin (RMP) for chemotherapy of pulmonary tuberculosis are cheaper and can be usually supervised more easily than daily regimens. They are recommended, specially, in developing countries. The present study is designed to evaluate the reduction of RMP activity as the interval between doses is increased in experimental mouse tuberculosis. The mice are given 10 mg/kg oral doses of RMP once, twice, three times or six times a week. The RMP activity is measured as the decrease of viable counts (cfu) in the spleen of mice. RMP given once a week has no activity neither in combination with isoniazid and streptomycin on a large population of organisms nor alone on a small population. RMP given alone twice a week has an activity slightly better than RMP given once a week. RMP given alone three times a week has a weak but not worthy activity: the mean number of cfu after a three times weekly treatment is significantly lower than the mean number of cfu in control (p less than 0.001) but significantly higher than the mean number of cfu after a six times weekly treatment (p less than 0.001). These experimental results are consistent with the experimental data on the effects of RMP on the RNA polymerase. They are not favourable to the intermittent administration of RMP in the chemotherapy of tuberculosis.
用于肺结核化疗的含利福平（RMP）间歇疗法比每日疗法更便宜，且通常更容易进行监督。特别在发展中国家，推荐使用间歇疗法。本研究旨在评估在实验性小鼠结核病中，随着给药间隔时间增加利福平活性的降低情况。给小鼠每周口服10毫克/千克剂量的利福平一次、两次、三次或六次。利福平活性通过小鼠脾脏中活菌数（cfu）的减少来衡量。每周给药一次的利福平，无论是与异烟肼和链霉素联合用于大量细菌群体，还是单独用于少量细菌群体，均无活性。单独每周给药两次的利福平活性略优于每周给药一次的利福平。单独每周给药三次的利福平具有微弱但不值得一提的活性：每周三次治疗后的cfu平均数显著低于对照组的cfu平均数（p小于0.001），但显著高于每周六次治疗后的cfu平均数（p小于0.001）。这些实验结果与利福平对RNA聚合酶作用的实验数据一致。它们不支持在结核病化疗中间歇使用利福平。
