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99mTc-DADS（99mTc-N，N'-双/巯基乙酰胺乙二胺）、99mTc-DTPA和131I-邻碘马尿酸肾闪烁显像特性及血浆清除率的比较评估

Comparative evaluation of renoscintigraphic properties and plasma clearance of 99MTc-DADS (99mTc-N,N'-bis/mercaptoacetamido ethylenediamine), 99mTc-DTPA and 131I-o-hippuran.

作者信息

Ogiński M, Liniecki J, Joachimiak J, Surma M, Białobrzeski J

出版信息

Nuklearmedizin. 1983 Jun;22(3):136-9.

PMID:6353374
Abstract

Plasma clearance of 99mTc-N,N'-bis (1,2-mercaptoacetamido) ethylenediamine (DADS), 99mTc-DTPA and 131I-o-hippuran (OIH) was determined in rabbits from blood-concentration decay curves after single i.v. injection of the compounds. Dynamic scintigraphy was performed using the same three compounds, and "activity" curves were compared as observed over kidney ROIs. Both clearance values and renoscintigraphic curves were similar for 99mTc-DADS and 99mTc-DTPA but evidently different from those of OIH. Biliary excretion of 99mTc-DADS was also observed. It appears that, in contrast to other authors, 99mTc-DADS cannot serve as a substitute for 131I-o-hippuran.

摘要

通过单次静脉注射化合物后兔血药浓度衰减曲线测定了99mTc-N，N'-双（1,2-巯基乙酰胺基）乙二胺（DADS）、99mTc-DTPA和131I-邻碘马尿酸（OIH）的血浆清除率。使用相同的三种化合物进行动态闪烁显像，并比较在肾脏感兴趣区观察到的“活性”曲线。99mTc-DADS和99mTc-DTPA的清除率值和肾闪烁显像曲线相似，但与OIH的明显不同。还观察到了99mTc-DADS的胆汁排泄。与其他作者的观点相反，99mTc-DADS似乎不能替代131I-邻碘马尿酸。

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