Stuart-Harris R, Buckman R, Starke I, Wiltshaw E
Postgrad Med J. 1983 Aug;59(694):500-3. doi: 10.1136/pgmj.59.694.500.
The use of cisplatin may be associated with severe nausea and vomiting. Two separate, randomized, double-blind trials, comparing the anti-emetic effect of chlorpromazine with placebo and chlorpromazine with droperidol, were conducted in patients receiving cisplatin for ovarian cancer. Chlorpromazine was statistically superior to placebo in the control of nausea and vomiting in those patients treated with chlorpromazine had significantly less nausea than with droperidol, but there were no other significant differences between chlorpromazine and droperidol. Toxicities of chlorpromazine and droperidol were similar. Chlorpromazine shows useful activity against cisplatin nausea and vomiting.
使用顺铂可能会导致严重的恶心和呕吐。针对接受顺铂治疗卵巢癌的患者，进行了两项独立的随机双盲试验，比较了氯丙嗪与安慰剂以及氯丙嗪与氟哌利多的止吐效果。在控制恶心和呕吐方面，氯丙嗪在统计学上优于安慰剂，接受氯丙嗪治疗的患者恶心程度明显低于接受氟哌利多治疗的患者，但氯丙嗪和氟哌利多之间没有其他显著差异。氯丙嗪和氟哌利多的毒性相似。氯丙嗪对顺铂引起的恶心和呕吐有显著疗效。
