Roberts W S, Wisniewski B J, Cavanagh D, Marsden D E
Oncology. 1985;42(1):42-3. doi: 10.1159/000225997.
23 patients received cis-platinum, doxorubicin and cyclophosphamide for gynecologic malignancy between December 1, 1980 and December 1, 1982. Each patient was randomized with each course of chemotherapy to receive intravenous droperidol or the combination of promethazine and chlorpromazine rectal suppositories as an antiemetic regimen. Both the rate and duration of emesis were significantly lower when droperidol was used as the antiemetic regimen. There were no major side effects with either regimen. Droperidol seems to be superior to the combination of promethazine and chlorpromazine rectal suppositories in alleviating cis-platinum-induced nausea and vomiting.
1980年12月1日至1982年12月1日期间，23例妇科恶性肿瘤患者接受了顺铂、阿霉素和环磷酰胺治疗。在每个化疗疗程中，每位患者被随机分配接受静脉注射氟哌利多或异丙嗪与氯丙嗪直肠栓剂联合使用作为止吐方案。当使用氟哌利多作为止吐方案时，呕吐的发生率和持续时间均显著降低。两种方案均未出现严重副作用。在缓解顺铂引起的恶心和呕吐方面，氟哌利多似乎优于异丙嗪与氯丙嗪直肠栓剂联合使用。
