肾素-血管紧张素系统在实验性肾血管性高血压中的作用
[Participation of the renin-angiotensin system in experimental renovascular hypertension].
作者信息
Salazar F J, García-Estañ J, Carbonell L F, Muñoz J A, Canteras M, Quesada T
出版信息
Rev Esp Fisiol. 1983 Jun;39(2):161-7.
PMID:6353502
Abstract
Hypertension was induced in Wistar rat by means of a clip in the left renal artery. After two weeks (acute stage) and sixteen weeks (chronic stage) the animals had a significant increase in arterial pressure (AP) and plasma renin activity (PRA). At both stages, nephrectomy or revascularization of the ischemic kidney returned AP and PRA to the normal level, both in the short term (1 day) and long term (60 days).
摘要
通过夹闭Wistar大鼠左肾动脉诱导高血压。两周（急性期）和十六周（慢性期）后，动物的动脉血压（AP）和血浆肾素活性（PRA）显著升高。在两个阶段，切除缺血肾或对缺血肾进行血管重建均可使AP和PRA在短期（1天）和长期（60天）内恢复至正常水平。
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