Førre O, Thoen J, Natvig J B
Semin Arthritis Rheum. 1983 Aug;13(1 Suppl 1):130-3. doi: 10.1016/0049-0172(83)90032-x.
The immune system is extremely complex. It comprises many different types of cells and their products. In patients with rheumatic diseases the immune system is activated and has disturbed regulation. It is also believed that immune reactions are involved in the pathogenesis of these disorders. Nonsteroidal antiinflammatory drugs (NSAID) have therapeutic effects on rheumatic diseases. These effects can all be explained by inhibition of prostaglandin production locally in the diseased joints, leading to reduced inflammation. Little or no effects on the number of circulating lymphocyte subpopulations or on peripheral blood mononuclear cell immune reactions can be seen after treatment of patients with rheumatoid arthritis (RA) with NSAID. The possibility, however, exists that immune reactions locally in the diseased joints are modulated by NSAID secondary to reduced prostaglandin production.
免疫系统极其复杂。它由许多不同类型的细胞及其产物组成。在风湿性疾病患者中，免疫系统被激活且调节紊乱。人们还认为免疫反应参与了这些疾病的发病机制。非甾体抗炎药（NSAID）对风湿性疾病有治疗作用。这些作用都可以通过抑制患病关节局部前列腺素的产生来解释，从而减轻炎症。类风湿关节炎（RA）患者用NSAID治疗后，对循环淋巴细胞亚群数量或外周血单核细胞免疫反应几乎没有影响。然而，NSAID可能通过减少前列腺素的产生，继而调节患病关节局部的免疫反应。
