Heineman E, Marquet R L, Jeekel J
Transplantation. 1983 Oct;36(4):362-5. doi: 10.1097/00007890-198310000-00002.
In the BN/Ro-to-WAG/Ro rat donor-host combination, third-party blood transfusions given to the donor shortly before transplantation can markedly influence heart allograft survival if the immune response of the recipient has been modulated. The WAG recipients were either transfused with BN donor blood, which leads to a permanent graft survival, or postoperatively treated with a single i.m. injection of 15 mg/kg cyclosporine, which leads to a moderate prolongation of graft survival. In the transfused recipients, blood transfusions to the donor had a detrimental influence on graft survival. In the cyclosporine-treated recipients, blood transfusions to the donor had a beneficial effect. There was no significant difference in graft survival after a single transfusion or multiple transfusions to the donor. Recipient-type blood transfusion to the donor did not influence graft survival, nor did irradiated third-party blood or third-party erythrocytes. However, third-party leukocyte suspensions had a significant influence on heart allograft survival. It is concluded that third-party viable leukocytes are responsible for the induction of the donor transfusion phenomenon. It is also postulated that the third-party leukocytes interact with the dendritic cell population of the graft, leading to a reduction in its immunogenicity.
在BN/Ro到WAG/Ro大鼠供体-受体组合中，如果受体的免疫反应已被调节，在移植前不久给供体进行第三方输血可显著影响心脏同种异体移植物的存活。WAG受体要么输注BN供体血液（这会导致移植物永久存活），要么术后单次肌肉注射15 mg/kg环孢素（这会导致移植物存活适度延长）。在接受输血的受体中，给供体输血对移植物存活有不利影响。在接受环孢素治疗的受体中，给供体输血有有益作用。给供体单次输血或多次输血后，移植物存活无显著差异。给供体输注受体型血液不影响移植物存活，照射过的第三方血液或第三方红细胞也不影响。然而，第三方白细胞悬液对心脏同种异体移植物存活有显著影响。得出的结论是，第三方活白细胞是诱导供体输血现象的原因。还推测第三方白细胞与移植物的树突状细胞群体相互作用，导致其免疫原性降低。
