Niessen G J, Marquet R L, Bijnen A B, Obertop H, Jeekel J
Surgery. 1982 Mar;91(3):339-42.
Blood transfusions may have a beneficial or deleterious effect on graft survival. The purpose of the present study was to see whether cyclosporin A (CyA) could overcome the sensitizing effect of pretransplant blood transfusions and whether it would alter the beneficial effect of blood transfusions. Therefore, the effect of CyA was studied in transfused and nontransfused recipients by use of a rat cardiac allograft model. The BN/Ro and Wag/Ro strains were used. Each strain rejects a heart allograft from the other in 8 to 9 days when nontransfused recipients are involved. After conditioning with one donor-specific pretransplant blood transfusion, accelerated rejection is seen in the Wag/Ro to BN/Ro combination, whereas indefinite survival occurs in the reverse combination. CyA treatment results in indefinite graft survival in nonsensitized recipients of both strains but at a lower dosage in the BN/Ro to Wag/Ro combination. In transfused BN/Ro recipients, CyA prolongs heart allograft survival indefinitely, although higher doses are required (15 mg/kg) than in nonsensitized recipients; in the reverse combination, CyA does not interfere with the beneficial blood transfusion effect. The findings that CyA can prevent accelerated rejection in the Wag/Ro to BN/Ro combination and that it does not alter the beneficial effect in the reverse combination might mean that CyA is a useful drug even in sensitized recipients.
输血对移植物存活可能有有益或有害的影响。本研究的目的是观察环孢素A（CyA）是否能克服移植前输血的致敏作用，以及它是否会改变输血的有益效果。因此，通过大鼠心脏同种异体移植模型，研究了CyA在输血和未输血受体中的作用。使用了BN/Ro和Wag/Ro品系。当涉及未输血受体时，每个品系在8至9天内排斥来自另一个品系的心脏同种异体移植物。在进行一次供体特异性移植前输血预处理后，在Wag/Ro到BN/Ro的组合中可见加速排斥，而在相反组合中则出现无限期存活。CyA治疗可使两个品系的未致敏受体的移植物无限期存活，但在BN/Ro到Wag/Ro的组合中所需剂量较低。在输血的BN/Ro受体中，CyA可无限期延长心脏同种异体移植物的存活时间，尽管所需剂量（15mg/kg）高于未致敏受体；在相反组合中，CyA不会干扰输血的有益效果。CyA可预防Wag/Ro到BN/Ro组合中的加速排斥，且在相反组合中不改变有益效果，这些发现可能意味着CyA即使在致敏受体中也是一种有用的药物。
