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[威奴伦——淋病的替代单剂量疗法]

[Winuron - alternative single-dose therapy of gonorrhea].

作者信息

Fechner W C, Hahn S, Mac Lean N, Eisele R

出版信息

Z Hautkr. 1983 Aug 15;58(16):1165-76.

PMID:6353787
Abstract

152 ambulatory patients suffering from gonorrhoea were treated with Winuron in an open clinical trial. A single oral dose of rosoxacin 300 mg proved to be sufficient to cure 97.4% of the patients. Follow-up examination revealed only 4 cases of Neisseria gonorrhoea left. Already 3 days after therapy, the clinical symptoms had subsided in 84.1% of the patients. The substance was well-tolerated. Side effects were observed in 14.5% of the cases, being mild and transitory, though. Good and antibacterial efficacy of rosoxacin in vitro as well as the high healing quotient in combination with the shortest possible duration of therapy make Winuron a valuable alternative to penicillin.

摘要

在一项开放性临床试验中,152例门诊淋病患者接受了维诺隆治疗。单次口服300毫克罗索沙星被证明足以治愈97.4%的患者。随访检查仅发现4例淋病奈瑟菌残留。治疗后仅3天,84.1%的患者临床症状就已消退。该药物耐受性良好。14.5%的病例观察到有副作用,但均为轻度且短暂的。罗索沙星在体外具有良好的抗菌效果,且结合最短的治疗时间具有较高的治愈率,这使得维诺隆成为青霉素的一种有价值的替代品。

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