Lei D N, Elias J M
Am J Clin Pathol. 1983 Oct;80(4):436-40. doi: 10.1093/ajcp/80.4.436.
It is believed that the immature precursor cells of gastric mucosa have multidirectional potency of differentiation and these cells can differentiate into both endocrine and nonendocrine tumor cells. Fifteen cases of surgically resected stomach with gastric nonendocrine carcinoma were studied by the three-layer immunoperoxidase method. Serotonin was found in five cases, gastrin in one case, and both serotonin and gastrin in three cases. Serotonin also was detected in the noncancerous mucosa in thirteen cases: ten showing positive cells in the antrum and seven in the body. Gastrin was found in the noncancerous mucosa in 13 cases: eight in the antrum, five in the body. In four cases, a few serotonin positive cells were found in glands showing intestinal metaplasia. No correlation was found between the endocrine tumor cells and the types of carcinoma. Because endocrine cells can be detected in general types of gastric carcinoma, these findings suggest that the different kinds of cancer cells (endocrine and nonendocrine) may have a common origin.
据信，胃黏膜未成熟前体细胞具有多向分化潜能，这些细胞可分化为内分泌和非内分泌肿瘤细胞。采用三层免疫过氧化物酶法对15例手术切除的胃非内分泌癌病例进行了研究。在5例中发现了血清素，1例中发现了胃泌素，3例中同时发现了血清素和胃泌素。在13例非癌黏膜中也检测到了血清素：10例胃窦部显示阳性细胞，7例胃体部显示阳性细胞。在13例非癌黏膜中发现了胃泌素：8例在胃窦部，5例在胃体部。在4例中，在显示肠化生的腺体中发现了少量血清素阳性细胞。未发现内分泌肿瘤细胞与癌的类型之间存在相关性。由于在一般类型的胃癌中均可检测到内分泌细胞，这些发现提示不同类型的癌细胞（内分泌和非内分泌）可能有共同的起源。
