Haven G T, Tholen D W, Oxley D K
Am J Clin Pathol. 1983 Oct;80(4 Suppl):615-21.
Six paired specimens distributed to laboratories in 1981 at approximately three-month intervals and four paired specimens distributed to laboratories in 1976 at intervals of three to nine months for analysis by the College of American Pathologists Survey form the basis for this study. Twelve of 37 (35%) of pool-analyte-technic combinations yielded significantly changed mean values in 1976, while 34 of 196 (17%) pool-analyte-technic combinations yielded significantly changed values in 1981. Probable instability in thyroxine and folate was demonstrated in the 1981 control pools. Precision generally continued to improve from 1976 to 1981. The poorest precision now is observed in the analysis of peptide hormones. A majority of the observed analytic variation during 1981 for most analytes relates to extralaboratory factors. Improvement in performance is largely dependent on intermanufacturer standardization of procedures and long-term maintenance of equivalence of the results of kit procedures by each manufacturer.
1981年每隔约三个月向各实验室分发六对标本，1976年每隔三至九个月向各实验室分发四对标本，由美国病理学家学会调查进行分析，这些标本构成了本研究的基础。1976年，37种（35%）混合分析物-技术组合中有12种产生了显著变化的均值，而1981年，196种（17%）混合分析物-技术组合中有34种产生了显著变化的值。1981年的对照样本显示甲状腺素和叶酸可能存在不稳定性。从1976年到1981年，精密度总体上持续提高。目前在肽类激素分析中观察到精密度最差。1981年大多数分析物观察到的分析变异大部分与实验室外部因素有关。性能的提高在很大程度上取决于各制造商之间程序的标准化以及各制造商对试剂盒程序结果等效性的长期维持。
