Iregbulem L M
Ann Acad Med Singap. 1983 Apr;12(2 Suppl):425-9.
Most published studies on the use of a semi-permeable membrane dressing (opsite) on split-skin donor sites have been on Caucasians. To assess this new method on the black population of a developing country where donor sites are notoriously slow to heal, a study was conducted on fifty Nigerians of varying age groups in whom split-skin grafts of identical thickness were taken from both thighs by the same surgeon: 100 donor sites were studied. In all the patients one thigh was dressed with the conventional sofratulle and the other with opsite. The allocation was made randomly. Twenty-five donor sites (53.4%) treated with sofratulle healed by the 13th postoperative day. By contrast, thirty donor sites (62.5%) treated with opsite healed by the 7th postoperative day. All opsite treated wounds were completely healed by the 11th day but it took nearly four weeks for the sofratulle treated thighs to heal. Minimal discomfort was experienced by 10% of the patients treated with opsite but about 80% of those treated with sofratulle required mild analgesics on ambulation during the first 48 hours on account of pain. Opsite effectively reduces healing time in donor sites, is easy to apply, less bulky to use, painfree and well tolerated by patients.
大多数已发表的关于在分层皮片供皮区使用半透膜敷料（Opsite）的研究都是针对白种人进行的。为了在一个发展中国家的黑人人群中评估这种新方法，在这个国家供皮区愈合 notoriously 缓慢，对五十名不同年龄组的尼日利亚人进行了一项研究，由同一位外科医生从他们的双侧大腿取相同厚度的分层皮片：共研究了100个供皮区。在所有患者中，一侧大腿用传统的 Sofratulle 敷料包扎，另一侧用 Opsite 敷料包扎。分配是随机进行的。用 Sofratulle 治疗的25个供皮区（53.4%）在术后第13天愈合。相比之下，用 Opsite 治疗的30个供皮区（62.5%）在术后第7天愈合。所有用 Opsite 治疗的伤口在第11天完全愈合，但用 Sofratulle 治疗的大腿愈合需要近四周时间。用 Opsite 治疗的患者中有10%仅有轻微不适，而用 Sofratulle 治疗的患者中约80%在头48小时行走时因疼痛需要使用轻度镇痛药。Opsite 能有效缩短供皮区的愈合时间，易于应用，使用时体积较小，无痛且患者耐受性良好。
