Churkina L N, Vasiurenko Z P, Smirnov V V, Kiprianova E A, Garagulia A D
Antibiotiki. 1983 Jul;28(7):489-94.
The effect of antibiotic A1-87 on the fatty acid composition of S. aureus 209, E. coli O26 and M. luteus 169 significantly differing in this property was studied. The sub-bacteriostatic doses of the preparation induced the appearance of unsaturated fatty acids in S. aureus 209. These acids were not detected in the control cultures. They also significantly increased the content of the saturated branched fatty acid with 15 carbon atoms in this culture and decreased the content of the fatty acid of the same type with 19 carbon atoms. In E. coli O25 there was an almost two-fold increase in the content of the unsaturated straight chain fatty acids with a respective decrease in the content of cyclopropanoic acid and a markedly pronounced decrease in the content of nonadecanoic acid. In M. luteus 169 the content of the saturated branched fatty acid with 15 carbon atoms increased, while the content of the unsaturated straight chain fatty acids (C16:1, C18:1) decreased, the content of hexadecanoic acid being decreased almost two times. According to the present status the differences in the fatty acid composition of the above organisms are interpreted as one of the mechanisms increasing the membrane permeability.
