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[抗生素AL-87对金黄色葡萄球菌209P敏感菌株磷脂和中性脂质脂肪酸组成变化的诱导作用]

[Antibiotic AL-87 induction of changes in the fatty acid composition of phospholipids and neutral lipids in a sensitive strain of Staphylococcus aureus 209P].

作者信息

Smirnov V V, Churkina L N, Vasiurenko Z P

出版信息

Antibiot Khimioter. 1988 Jun;33(6):440-3.

PMID:3421768
Abstract

Under the action of the sub-bacteriostatic concentration (0.02 microgram/ml) of antibiotic AL-87 there formed in all the fractions of phospholipids and neutral lipids of S. aureus 209P unsaturated branched fatty acids not detected in the control and the content of shorter chain saturated branched fatty acids increased. This means that there were changes leading to increased lipid fluidity. The findings showed that fatty acids of the neutral lipids and phospholipids were involved in regulation of the bacterial cell functional state and participated in this case in providing increased membrane fluidity and permeability.

摘要

在抗生素AL - 87的亚抑菌浓度(0.02微克/毫升)作用下,金黄色葡萄球菌209P的所有磷脂和中性脂质组分中均形成了对照中未检测到的不饱和支链脂肪酸,且短链饱和支链脂肪酸的含量增加。这意味着发生了导致脂质流动性增加的变化。研究结果表明,中性脂质和磷脂的脂肪酸参与了细菌细胞功能状态的调节,在这种情况下参与了增加膜流动性和通透性的过程。

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