Dysart N K, Sisson S, Vernier R L
Clin Immunol Immunopathol. 1983 Nov;29(2):254-70. doi: 10.1016/0090-1229(83)90028-4.
The distribution of IgA, IgG, IgM, C3, and albumin in kidney biopsy specimens from 11 children and adults with recurrent gross and microscopic hematuria and IgA nephropathy and 7 control specimens were evaluated by the direct peroxidase-labeled antibody method and electron microscopy. Granular masses of reaction product (RP), representing IgA, IgG, IgM, and C3, were observed within the mesangial matrix of glomeruli from all patients with IgA nephropathy. Occasional smaller masses of IgA-RP and C3-RP were noted along the peripheral glomerular capillary loops, the tubular basement membranes, and within the interstitial matrix of some patients. Large amounts of IgA-RP and C3-RP were present within the walls of small renal arterioles of several patients. These observations support the concept that immune-complex deposits are involved in the pathogenesis of IgA nephropathy and suggest that vascular deposits may have a more important role in the progression of the disease in some patients.
采用直接过氧化物酶标记抗体法和电子显微镜，对11例患有复发性肉眼血尿和镜下血尿的儿童及成人IgA肾病患者的肾活检标本以及7例对照标本中的IgA、IgG、IgM、C3和白蛋白分布情况进行了评估。在所有IgA肾病患者的肾小球系膜基质内均观察到代表IgA、IgG、IgM和C3的颗粒状反应产物（RP）团块。在部分患者的肾小球外周毛细血管袢、肾小管基底膜以及间质基质中偶尔可见较小的IgA-RP和C3-RP团块。在部分患者的小肾动脉壁内存在大量的IgA-RP和C3-RP。这些观察结果支持免疫复合物沉积参与IgA肾病发病机制的观点，并表明血管内沉积在部分患者疾病进展过程中可能发挥更重要的作用。
